The Pfizer Inc drug, also known as celecoxib, works by blocking the COX-2 enzyme that causes inflammation, which has been linked with cancer. A six-month study of 212 current or heavy smokers found a reduction in a specific type of precancerous change in lung cells in people who took a high dose of Celebrex compared with those who took a placebo.
None of the study participants had any heart-related problems such as those with Merck & Co Inc's now withdrawn arthritis drug Vioxx, another COX-2 inhibitor.
"Celebrex was safe and we did not see any cardiovascular events," said Dr. Edward Kim of M.D. Anderson Cancer Center in Houston, who presented his findings at a meeting of the American Society of Clinical Oncology in Chicago.
He said the study suggests that a high dose of Celebrex might alter some of the cellular changes that lead up to lung cancer. But the finding is very early and would need to be confirmed in longer, larger studies.
No comments:
Post a Comment